Ontology highlight
ABSTRACT:
SUBMITTER: Swystun LL
PROVIDER: S-EPMC6118640 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Swystun Laura L LL Lai Jesse D JD Notley Colleen C Georgescu Ilinca I Paine A Simonne AS Mewburn Jeff J Nesbitt Kate K Schledzewski Kai K Géraud Cyrill C Kzhyshkowska Julia J Goerdt Sergij S Hopman Wilma W Montgomery Robert R RR James Paula D PD Lillicrap David D
The Journal of clinical investigation 20180820 9
Quantitative abnormalities of the von Willebrand factor-factor VIII (VWF-FVIII) complex associate with inherited bleeding or thrombotic disorders. Receptor-mediated interactions between plasma VWF-FVIII and phagocytic or immune cells can influence their hemostatic and immunogenic activities. Genetic association studies have demonstrated that variants in the STAB2 gene, which encodes the scavenger receptor stabilin-2, associate with plasma levels of VWF-FVIII. However, the mechanistic basis and p ...[more]