Ontology highlight
ABSTRACT:
SUBMITTER: Keller JA
PROVIDER: S-EPMC6119086 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Keller Jason A JA Chen Jingyi J Simpson Sierra S Wang Eric Hou-Jen EH Lilascharoen Varoth V George Olivier O Lim Byung Kook BK Stowers Lisa L
Nature neuroscience 20180813 9
Voluntary urination ensures that waste is eliminated when safe and socially appropriate, even without a pressing urge. Uncontrolled urination, or incontinence, is a common problem with few treatment options. Normal urine release requires a small region in the brainstem known as Barrington's nucleus (Bar), but specific neurons that relax the urethral sphincter and enable urine flow are unknown. Here we identify a small subset of Bar neurons that control the urethral sphincter in mice. These excit ...[more]