Dataset Information
Kinetics of Cytokine Levels during Antipsychotic Treatment in Schizophrenia: A Meta-Analysis.
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ABSTRACT: Background
Immune system dysfunction is a hypothesis in the psychopathology of schizophrenia, but the impact of antipsychotic treatment within this system is not clear. The aim of this meta-analysis was to investigate the impact of antipsychotic treatment on cytokine levels in in vivo studies on schizophrenia.Methods
After a systematic database search, original data were extracted with the help of certain authors. Means and SDs were extracted to calculate standardized mean differences. Cytokine levels were compared in vivo in schizophrenia patients, before and after antipsychotic treatment. Meta-regressions were performed to explore the influence of demographic and clinical variables on cytokine level standardized mean differences. Stratifications by treatment and diagnosis were also performed.Results
Forty-seven studies were included in this meta-analysis. Proinflammatory cytokine level decreases were found for interleukin-1 ? levels (P<.0001) and interferon-? (P=.01) and a statistical trend towards a decrease in interleukin-6 (P=.08) and tumor necrosis factor-? (P=.07) levels. An antiinflammatory cytokine level increase was found for soluble tumor necrosis factor-R2 (P<.001) and soluble interleukin 2-R (P=.03) levels. A meta-regression analysis found a correlation between interleukin-6 level standardized mean differences and positive schizophrenia symptom score standardized mean differences before and after treatment (P=.01). Stratification by diagnosis or treatment found a possible impact of the kinetics of cytokine levels.Conclusions
The present meta-analysis provides evidence that antipsychotic treatment has an antiinflammatory effect and could normalize immune balance dysfunction in schizophrenia. Interleukin-6 level normalization could be a marker of illness equilibration and thus used in clinical practice.
SUBMITTER: Romeo B
PROVIDER: S-EPMC6119290 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Kinetics of Cytokine Levels during Antipsychotic Treatment in Schizophrenia: A Meta-Analysis.
The international journal of neuropsychopharmacology 20180901 9
<h4>Background</h4>Immune system dysfunction is a hypothesis in the psychopathology of schizophrenia, but the impact of antipsychotic treatment within this system is not clear. The aim of this meta-analysis was to investigate the impact of antipsychotic treatment on cytokine levels in in vivo studies on schizophrenia.<h4>Methods</h4>After a systematic database search, original data were extracted with the help of certain authors. Means and SDs were extracted to calculate standardized mean differ ...[more]