Dataset Information

A case of Phaeohyphomycosis caused by Corynespora cassiicola infection.

ABSTRACT:

Background

Corynespora cassiicola infection is common in plants, but the human Corynespora cassiicola infection in our report is rare according to the literature.

Case presentation

We report a case of subcutaneous phaeohyphomycosis caused by a plant pathogen in a patient with acute heart failure. The organism was isolated and identified as Corynespora cassiicola according to its morphological characteristics and gene analysis. The patient was treated successfully with systemic voriconazole.

Conclusions

This is the third reported case of subcutaneous infection caused by Corynespora cassiicola and the first reported case with accompanied renal impairment, which was associated with acute heart failure. Our case also suggests the importance of renal function monitoring in patients receiving intravenous voriconazole treatment.

SUBMITTER: Xie Z

PROVIDER: S-EPMC6119301 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

A case of Phaeohyphomycosis caused by Corynespora cassiicola infection.

Xie Zhaolu Z Wu Wei W Meng Desheng D Zhang Qing Q Ma Yunqi Y Liu Wen W Chen Jianhong J

BMC infectious diseases 20180831 1

<h4>Background</h4>Corynespora cassiicola infection is common in plants, but the human Corynespora cassiicola infection in our report is rare according to the literature.<h4>Case presentation</h4>We report a case of subcutaneous phaeohyphomycosis caused by a plant pathogen in a patient with acute heart failure. The organism was isolated and identified as Corynespora cassiicola according to its morphological characteristics and gene analysis. The patient was treated successfully with systemic vor ...[more]

PMID: 30170557

Similar Datasets

Project description:Corynespora cassiicola is an Ascomycetes fungus with a broad host range and diverse life styles. Mostly known as a necrotrophic plant pathogen, it has also been associated with rare cases of human infection. In the rubber tree, this fungus causes the Corynespora leaf fall (CLF) disease, which increasingly affects natural rubber production in Asia and Africa. It has also been found as an endophyte in South American rubber plantations where no CLF outbreak has yet occurred. The C. cassiicola species is genetically highly diverse, but no clear relationship has been evidenced between phylogenetic lineage and pathogenicity. Cassiicolin, a small glycosylated secreted protein effector, is thought to be involved in the necrotrophic interaction with the rubber tree but some virulent C. cassiicola isolates do not have a cassiicolin gene. This study set out to identify other putative effectors involved in CLF. The genome of a highly virulent C. cassiicola isolate from the rubber tree (CCP) was sequenced and assembled. In silico prediction revealed 2870 putative effectors, comprising CAZymes, lipases, peptidases, secreted proteins and enzymes associated with secondary metabolism. Comparison with the genomes of 44 other fungal species, focusing on effector content, revealed a striking proximity with phylogenetically unrelated species (Colletotrichum acutatum, Colletotrichum gloesporioides, Fusarium oxysporum, nectria hematococca, and Botrosphaeria dothidea) sharing life style plasticity and broad host range. Candidate effectors involved in the compatible interaction with the rubber tree were identified by transcriptomic analysis. Differentially expressed genes included 92 putative effectors, among which cassiicolin and two other secreted singleton proteins. Finally, the genomes of 35 C. cassiicola isolates representing the genetic diversity of the species were sequenced and assembled, and putative effectors identified. At the intraspecific level, effector-based classification was found to be highly consistent with the phylogenomic trees. Identification of lineage-specific effectors is a key step toward understanding C. cassiicola virulence and host specialization mechanisms.

Dataset Information

A case of Phaeohyphomycosis caused by Corynespora cassiicola infection.

Background

Case presentation

Conclusions

Publications

A case of Phaeohyphomycosis caused by Corynespora cassiicola infection.

Similar Datasets

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