Dataset Information

Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.

ABSTRACT:

Objectives

The level of vitamin D is considered to be associated with the development and progression of heart failure (HF). However, it is still unclear whether supplementation of vitamin D could improve ventricular remodelling in patients with HF. This study aimed to systematically evaluate the influence and safety of additional vitamin D supplementation on ventricular remodelling in patients with HF.

Design

This study is a meta-analysis of randomised controlled trials (RCTs).

Setting

The PubMed, EMBASE, CNKI, Cochrane library, Web of Science databases and grey literature were searched for RCTs regarding the effect of vitamin D on ventricular remodelling in patients with HF (from database creation to October 2017). RevMan V.5.3 software was employed for data analysis.

Participants

Seven RCTs with a total of 465 patients, including 235 cases in the vitamin D group and 230 cases in the control group, were included.

Primary and secondary outcome measures

Left ventricular end-diastolic dimension (LVEDD), left ventricular ejection fraction (LVEF) and the incidence of adverse reactions.

Results

Compared with the control group, a decrease in the LVEDD (mean difference (MD)=-2.31?mm, 95% CI -4.15 to -0.47, p=0.01) and an increase in the LVEF (MD=4.18%, 95%?CI 0.36 to 7.99, p=0.03) were observed in the vitamin D group. Subgroup analysis also revealed a reduced LVEDD in adults (>18 years) and adolescents (<18 years) of the vitamin D group relative to that in those of the control group. High-dose vitamin D (>4000?IU/day) was more effective at reducing the LVEDD than low-dose vitamin D (<4000?IU/day). Moreover, vitamin D supplementation was more effective at reducing the LVEDD and increasing the LVEF in patients with reduced ejection fraction than in patients without reduced ejection fraction.

Conclusion

Vitamin D supplementation inhibits ventricular remodelling and improves cardiac function in patients with HF.

Trial registration number

CRD42017073893.

SUBMITTER: Zhao JD

PROVIDER: S-EPMC6119442 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Publications

Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.

Zhao Jin-Dong JD Jia Jing-Jing JJ Dong Ping-Shuan PS Zhao Di D Yang Xu-Ming XM Li Dao-Lin DL Zhang Hui-Feng HF

BMJ open 20180830 8

<h4>Objectives</h4>The level of vitamin D is considered to be associated with the development and progression of heart failure (HF). However, it is still unclear whether supplementation of vitamin D could improve ventricular remodelling in patients with HF. This study aimed to systematically evaluate the influence and safety of additional vitamin D supplementation on ventricular remodelling in patients with HF.<h4>Design</h4>This study is a meta-analysis of randomised controlled trials (RCTs).<h ...[more]

PMID: 30166289

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Dataset Information

Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.

Objectives

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusion

Trial registration number

Publications

Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.

Similar Datasets

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