Citrullinated histone 3 causes endothelial barrier dysfunction.
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ABSTRACT:
SUBMITTER: Meegan JE
PROVIDER: S-EPMC6119499 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Citrullinated histone 3 causes endothelial barrier dysfunction.
Meegan Jamie E JE Yang Xiaoyuan X Beard Richard S RS Jannaway Melanie M Chatterjee Victor V Taylor-Clark Thomas E TE Yuan Sarah Y SY
Biochemical and biophysical research communications 20180717 3
Circulating components of neutrophil extracellular traps (NETs), especially histones, are associated with tissue injury during inflammatory conditions like sepsis. Commonly used as a NET biomarker, citrullinated histone 3 (H3Cit) may also functionally contribute to the NET-associated inflammatory response. To this end, we sought to examine the role of H3Cit in mediating microvascular endothelial barrier dysfunction. Here we show that H3Cit can directly contribute to inflammatory injury by disrup ...[more]
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