Ontology highlight
ABSTRACT:
SUBMITTER: Tekin E
PROVIDER: S-EPMC6119685 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tekin Elif E White Cynthia C Kang Tina Manzhu TM Singh Nina N Cruz-Loya Mauricio M Damoiseaux Robert R Savage Van M VM Yeh Pamela J PJ
NPJ systems biology and applications 20180903
Interactions and emergent processes are essential for research on complex systems involving many components. Most studies focus solely on pairwise interactions and ignore higher-order interactions among three or more components. To gain deeper insights into higher-order interactions and complex environments, we study antibiotic combinations applied to pathogenic <i>Escherichia coli</i> and obtain unprecedented amounts of detailed data (251 two-drug combinations, 1512 three-drug combinations, 567 ...[more]