Ontology highlight
ABSTRACT:
SUBMITTER: Lau CI
PROVIDER: S-EPMC6119767 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Lau Ching-In CI Yánez Diana C DC Solanki Anisha A Papaioannou Eleftheria E Saldaña José Ignacio JI Crompton Tessa T
Journal of autoimmunity 20180727
The Foxa1 and Foxa2 transcription factors are essential for mouse development. Here we show that they are expressed in thymic epithelial cells (TEC) where they regulate TEC development and function, with important consequences for T-cell development. TEC are essential for T-cell differentiation, lineage decisions and repertoire selection. Conditional deletion of Foxa1 and Foxa2 from murine TEC led to a smaller thymus with a greater proportion of TEC and a greater ratio of medullary to cortical T ...[more]