Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables.
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ABSTRACT:
SUBMITTER: Weyerhauser P
PROVIDER: S-EPMC6120043 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Re-purposing Chloroquine for Glioblastoma: Potential Merits and Confounding Variables.
Weyerhäuser Patrick P Kantelhardt Sven R SR Kim Ella L EL
Frontiers in oncology 20180827
There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy-refractory cancers including glioblastoma, one of the most aggressive human cancers. While there is considerable evidence for the efficacy and safety of chloroquine the mechanisms underlying the tumor suppressive actions of this drug remain elusive. Up ...[more]
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