Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes.
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ABSTRACT:
SUBMITTER: Skrzypczyk A
PROVIDER: S-EPMC6120260 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes.
Skrzypczyk Aniela A Kehr Stephanie S Krystel Ilona I Bernhart Stephan H SH Giri Shibashish S Bader Augustinus A Stadler Peter F PF
Stem cells international 20180819
Recent advances in the stem cell field allow to obtain many human tissues in vitro. However, hepatic differentiation of induced pluripotent stem cells (iPSCs) still remains challenging. Hepatocyte-like cells (HLCs) obtained after differentiation resemble more fetal liver hepatocytes. MicroRNAs (miRNA) play an important role in the differentiation process. Here, we analysed noncoding RNA profiles from the last stages of differentiation and compare them to hepatocytes. Our results show that HLCs m ...[more]
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