Ontology highlight
ABSTRACT:
SUBMITTER: Jones J
PROVIDER: S-EPMC6120509 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Jones Jeffrey J Mato Anthony A Coutre Steven S Byrd John C JC Furman Richard R RR Hillmen Peter P Osterborg Anders A Tam Constantine C Stilgenbauer Stephan S Wierda William G WG Heerema Nyla A NA Eckert Karl K Clow Fong F Zhou Cathy C Chu Alvina D AD James Danelle F DF O'Brien Susan M SM
British journal of haematology 20180605 4
Patients with chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) with deletion 17p [del(17p)] have poor outcomes with chemoimmunotherapy. Ibrutinib is indicated for the treatment of CLL/SLL, including del(17p) CLL/SLL, and allows for treatment without chemotherapy. This integrated analysis was performed to evaluate outcomes in 230 patients with relapsed/refractory del(17p) CLL/SLL from three ibrutinib studies. With a median of 2 prior therapies (range, 1-12), 18% and 79% of evalu ...[more]