Ontology highlight
ABSTRACT:
SUBMITTER: Hrdinka M
PROVIDER: S-EPMC6120666 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Hrdinka Matous M Schlicher Lisa L Dai Bing B Pinkas Daniel M DM Bufton Joshua C JC Picaud Sarah S Ward Jennifer A JA Rogers Catherine C Suebsuwong Chalada C Nikhar Sameer S Cuny Gregory D GD Huber Kilian Vm KV Filippakopoulos Panagis P Bullock Alex N AN Degterev Alexei A Gyrd-Hansen Mads M
The EMBO journal 20180719 17
RIPK2 mediates inflammatory signaling by the bacteria-sensing receptors NOD1 and NOD2. Kinase inhibitors targeting RIPK2 are a proposed strategy to ameliorate NOD-mediated pathologies. Here, we reveal that RIPK2 kinase activity is dispensable for NOD2 inflammatory signaling and show that RIPK2 inhibitors function instead by antagonizing XIAP-binding and XIAP-mediated ubiquitination of RIPK2. We map the XIAP binding site on RIPK2 to the loop between β2 and β3 of the N-lobe of the kinase, which is ...[more]