Inhibition gates supralinear Ca²⁺ signaling in Purkinje cell dendrites during practiced movements.

ABSTRACT: Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction with parallel fiber activity, a pairing that enhances climbing fiber-evoked Ca²⁺ signaling in PC dendrites. In vivo, climbing fibers spike continuously, including during movements when parallel fibers are simultaneously conveying sensorimotor information to PCs. Whether parallel fiber activity enhances climbing fiber Ca²⁺ signaling during motor behaviors is unknown. In mice, we found that inhibitory molecular layer interneurons (MLIs), activated by parallel fibers during practiced movements, suppressed parallel fiber enhanc

SUBMITTER: Gaffield MA 

PROVIDER: S-EPMC6120752 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature