Dataset Information

Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea.

ABSTRACT:

Purpose

To evaluate longitudinal changes in health-related quality of life and satisfaction after radical prostatectomy for the treatment of prostate cancer in Korean men.

Materials and methods

Data from patients with localized prostate cancer who underwent radical prostatectomy between January 2012 and December 2013 were analyzed. Patients completed the Expanded Prostate Cancer Index Composite questionnaire at scheduled clinic visits (baseline and 1, 3, 6, and 12 months post-surgery).

Results

Data from 211 men were evaluated. Urinary domain summary scores decreased postoperatively but improved over the 12-month follow-up period. Urinary function and incontinence had not recovered to baseline values at 12 months, whereas urinary bother and irritation/obstruction scores showed no differences from baseline at 12 months. Sexual function improved at each timepoint to 12 months but did not recover to baseline values; sexual bother was approximately 50% of baseline values at 12 months. Recovery of sexual function was significantly greater in patients who underwent robotic surgery versus those who underwent open surgery. At the end of the study period, 66.3% of patients were satisfied with the treatment they had received; multivariate analysis showed that only urinary function recovery was significantly associated with overall satisfaction.

Conclusions

Urinary outcomes and sexual outcomes had not returned to baseline at 12 months. Recovery of sexual function was significantly greater in patients who underwent robotic surgery. Only recovery of urinary function was significantly associated with overall satisfaction 12 months after radical prostatectomy in this cohort of Korean men.

SUBMITTER: Pak S

PROVIDER: S-EPMC6121025 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Publications

Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea.

Pak Sahyun S Kim Myong M Ahn Hanjong H

Investigative and clinical urology 20180823 5

<h4>Purpose</h4>To evaluate longitudinal changes in health-related quality of life and satisfaction after radical prostatectomy for the treatment of prostate cancer in Korean men.<h4>Materials and methods</h4>Data from patients with localized prostate cancer who underwent radical prostatectomy between January 2012 and December 2013 were analyzed. Patients completed the Expanded Prostate Cancer Index Composite questionnaire at scheduled clinic visits (baseline and 1, 3, 6, and 12 months post-surg ...[more]

PMID: 30182076

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Project description:BackgroundThis study aimed to assess the longitudinal health-related quality of life (HRQOL) using the Expanded Prostate Cancer Index Composite (EPIC) and HRQOL change between the nerve-sparing technique in Japanese men treated with robot-assisted radical prostatectomy (RARP).MethodsA total of 573 patients who received RARP were included in this study. EPIC questionnaire was administered before treatment and up to 36 months after RARP. Clinical recovery was defined as half of the standard deviation of the baseline score for each domain. We divided all patients into recovery group or nonrecovery group. The time from survey to each domain recovery was calculated using the Kaplan-Meier method. We compared the sexual and urinary score change between groups using analysis of variance to confirm the effect of nerve-sparing technique.ResultsThe median age was 67 years (interquartile range, 62-71 years). The mean score of all urinary domains worsened noticeably after 1 month. All postoperative urinary summary, function, and incontinence scores were significantly lower than preoperative scores up to 3 years post-RARP. Postoperative sexual summary and functional scores were significantly lower than preoperative score at all follow-up times throughout the 36 months. The recovery rate for the urinary incontinence domain was the lowest (44.5%), whereas the recovery rate for the urinary irritative-obstructive domain was the highest (73.7%). In the sexual domain, the bother domain had a higher recovery rate (73.0%) than the functional domain (29.7%). Although the recovery of sexual domains was slower compared with other domains, by 36 months after RARP, almost all values had recovered. Compared with other technique groups, bilateral intrafascial nerve-sparing group showed significantly decreased change in subscale scores before and after RARP in several sexual and urinary domain.ConclusionThe time course and extent of functional and bother domain recovery documented in this study may prove useful for RARP patient selection in Japan.

Project description:BackgroundThe purpose of this study is to describe Health-Related Quality of Life (HRQoL) of localized prostate cancer patients in an Active Surveillance (AS) program, and to compare them with those undergoing radical prostatectomy (RP), external-beam radiotherapy (XRT) and brachytherapy (BT).MethodsMulti-institutional pooled cross-sectional analysis on patients in an AS protocol: < 75 years old; pathologically confirmed LPC (maximum of three positive cylinders); Gleason score < 3 + 4; clinical stage T1a-T2b; and PSA < 15 ng/ml. Exclusion criteria for this study were: less than 6 months in AS, termination of AS protocol, or incomplete data. Patients in AS were matched with those treated with RP, XRT or BT from the 'Spanish Multicentric Study of Clinically Localized Prostate Cancer' cohort according to risk group, time from treatment selection to HRQoL survey, and age. Prostate-specific (EPIC) and generic (SF-36) HRQoL instruments were completed. Analysis was stratified by HRQoL survey moment (>or < 2.5 years from treatment selection), and age (>or < 70 years old).ResultsMedian of time from treatment selection to HRQoL survey in the total 396 patients (99 per treatment group) was 2.4 years (range 0.5-8.3). Patients in AS presented higher (better) urinary incontinence scores than RP ones in both stratus of time from treatment selection to HRQoL survey (92.6 vs 67.0 and 81.4 vs 64.4, p < 0.01). Patients in AS for < 2.5 years presented greater sexual scores than any active treatment (p < 0.01), but only statistically higher than RP for those in AS for longer than 2.5 years. The magnitude of the differences between AS and RP groups in both EPIC domains ranged from moderate (0.7 SD) to large (1.0 SD). Regardless of treatment applied, patients presented similar and slightly increased SF-36 scores than US general population reference norms. Nonetheless, patients in AS for < 2.5 years reported worse outcomes than other treatment groups on physical health domains, especially in bodily pain (0.5-0.6 SD), and vitality (0.6-0.8 SD).ConclusionsConsidering patients' well-being, AS can be a good therapeutic option due to the low impact caused on urinary continence and sexual function. However, longitudinal studies are required to take into account HRQoL evolution over time.

Dataset Information

Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea.

Purpose

Materials and methods

Results

Conclusions

Publications

Changes in health-related quality of life after radical prostatectomy for prostate cancer: A longitudinal cohort study in Korea.

Similar Datasets

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