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Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

ABSTRACT: We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess the relationship between genetic variation, DNA methylation and 139 complex traits. Using two-sample MR, we identified 1148 associations across 61 traits where genetic variants were associated with both proximal DNA methylation (i.e. cis-meQTL) and complex trait variation (P?

SUBMITTER: Richardson TG

PROVIDER: S-EPMC6121186 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease.

Richardson Tom G TG Haycock Philip C PC Zheng Jie J Timpson Nicholas J NJ Gaunt Tom R TR Davey Smith George G Relton Caroline L CL Hemani Gibran G

Human molecular genetics 20180901 18

We have undertaken a systematic Mendelian randomization (MR) study using methylation quantitative trait loci (meQTL) as genetic instruments to assess the relationship between genetic variation, DNA methylation and 139 complex traits. Using two-sample MR, we identified 1148 associations across 61 traits where genetic variants were associated with both proximal DNA methylation (i.e. cis-meQTL) and complex trait variation (P < 1.39 × 10-08). Joint likelihood mapping provided evidence that the genet ...[more]

PMID: 29893838

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