Ontology highlight
ABSTRACT:
SUBMITTER: Nadarajah N
PROVIDER: S-EPMC6121331 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nadarajah Noeline N Schulte Dörte D McConnell Vivienne V Martin-Almedina Silvia S Karapouliou Christina C Mortimer Peter S PS Jeffery Steve S Schulte-Merker Stefan S Gordon Kristiana K Mansour Sahar S Ostergaard Pia P
International journal of molecular sciences 20180801 8
Lymphedema is characterized by chronic swelling of any body part caused by malfunctioning or obstruction in the lymphatic system. Primary lymphedema is often considered genetic in origin. <i>VEGFC</i>, which is a gene encoding the ligand for the vascular endothelial growth factor receptor 3 (VEGFR3/FLT4) and important for lymph vessel development during lymphangiogenesis, has been associated with a specific subtype of primary lymphedema. Through Sanger sequencing of a proband with bilateral cong ...[more]