MTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases.

ABSTRACT: Chronological age represents the greatest risk factor for many life-threatening diseases, including neurodegeneration, cancer, and cardiovascular disease; ageing also increases susceptibility to infectious disease. Current efforts to tackle individual diseases may have little impact on the overall healthspan of older individuals, who would still be vulnerable to other age-related pathologies. However, recent progress in ageing research has highlighted the accumulation of senescent cells with chronological age as a probable underlying cause of pathological ageing. Cellular senescence is an essentially irreversible proliferation arrest mechanism that has important roles in development, wound healing, and preventing cancer, but it may limit tissue function and cause widespread inflammation wi

SUBMITTER: Walters HE 

PROVIDER: S-EPMC6121351 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature