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Trans-Ferulic Acid-4-?-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance.

ABSTRACT: Trans-ferulic acid-4-?-glucoside (C₁₆H₂₀O?, TFA-4?-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-?-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-?-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.

SUBMITTER: Xue C

PROVIDER: S-EPMC6121433 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance.

Xue Chong C Lu Huanyu H Liu Ying Y Zhang Jianbin J Wang Jiye J Luo Wenjing W Zhang Wenbin W Chen Jingyuan J

International journal of molecular sciences 20180808 8

Trans-ferulic acid-4-β-glucoside (C16H20O₉, TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeu ...[more]

PMID: 30096768

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