MTOR and Tumor Cachexia.
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ABSTRACT:
SUBMITTER: Duval AP
PROVIDER: S-EPMC6121479 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
mTOR and Tumor Cachexia.
Duval Adrian P AP Jeanneret Cheryl C Santoro Tania T Dormond Olivier O
International journal of molecular sciences 20180730 8
Cancer cachexia affects most patients with advanced forms of cancers. It is mainly characterized by weight loss, due to muscle and adipose mass depletion. As cachexia is associated with increased morbidity and mortality in cancer patients, identifying the underlying mechanisms leading to cachexia is essential in order to design novel therapeutic strategies. The mechanistic target of rapamycin (mTOR) is a major intracellular signalling intermediary that participates in cell growth by upregulating ...[more]
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