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From the Clinical Problem to the Basic Research-Co-Culture Models of Osteoblasts and Osteoclasts.

ABSTRACT: Bone tissue undergoes constant remodeling and healing when fracture happens, in order to ensure its structural integrity. In order to better understand open biological and clinical questions linked to various bone diseases, bone cell co-culture technology is believed to shed some light into the dark. Osteoblasts/osteocytes and osteoclasts dominate the metabolism of bone by a multitude of connections. Therefore, it is widely accepted that a constant improvement of co-culture models with both cell types cultured on a 3D scaffold, is aimed to mimic an in vivo environment as closely as possible. Although in recent years a considerable knowledge of bone co-culture models has been accumulated, there are still many open questions. We here try to summarize the actual knowledge and address open questions.

SUBMITTER: Zhu S

PROVIDER: S-EPMC6121694 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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From the Clinical Problem to the Basic Research-Co-Culture Models of Osteoblasts and Osteoclasts.

Zhu Sheng S Ehnert Sabrina S Rouß Marc M Häussling Victor V Aspera-Werz Romina H RH Chen Tao T Nussler Andreas K AK

International journal of molecular sciences 20180803 8

Bone tissue undergoes constant remodeling and healing when fracture happens, in order to ensure its structural integrity. In order to better understand open biological and clinical questions linked to various bone diseases, bone cell co-culture technology is believed to shed some light into the dark. Osteoblasts/osteocytes and osteoclasts dominate the metabolism of bone by a multitude of connections. Therefore, it is widely accepted that a constant improvement of co-culture models with both cell ...[more]

PMID: 30081523

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