Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.

ABSTRACT:

Importance

Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C-derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults.

Objective

To determine whether elevated suPAR levels are associated with renal disease progression in children with CKD.

Design, setting, and participants

Post hoc analysis of 2 prospectively followed up pediatric CKD cohorts, ie, the ESCAPE Trial (1999-2007) and the 4C Study (2010-2016), with serum suPAR level measured at enrollment and

SUBMITTER: Schaefer F 

PROVIDER: S-EPMC6121753 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature