Ontology highlight
ABSTRACT:
SUBMITTER: Meng B
PROVIDER: S-EPMC6121786 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Meng Bo B Wang Jun J Wang Quanli Q Serianni Anthony S AS Pan Qingfeng Q
Carbohydrate research 20180731
Molecular recognition of mannose-6-phosphate (M6P)-modified oligosaccharides by transmembrane M6P receptors is a key signaling event in lysosomal protein trafficking in vivo. Access to M6P-containing high-mannose N-glycans is essential to achieving a thorough understanding of the M6P ligand-receptor recognition process. Herein we report the application of a versatile and reliable chemical strategy to prepare asymmetric di-antennary M6P-tagged high-mannose oligosaccharides in >20% overall yield a ...[more]