Ontology highlight
ABSTRACT:
SUBMITTER: Kennelly JP
PROVIDER: S-EPMC6121921 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kennelly John P JP van der Veen Jelske N JN Nelson Randal C RC Leonard Kelly-Ann KA Havinga Rick R Buteau Jean J Kuipers Folkert F Jacobs René L RL
Journal of lipid research 20180714 9
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-α (CTα) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CTα exclusively in the intestinal epithelium of mice (CTα<sup>IKO</sup> mice). When fed a chow diet, CTα<sup>IKO</sup> mice showed normal fat absorption despite a ∼30% decrease in intestinal PC concentrations relative to control mice, suggesting that biliary PC can fully supp ...[more]