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Cobalt-catalyzed nucleophilic addition of the allylic C(sp³)-H bond of simple alkenes to ketones.

ABSTRACT: We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities. The intermediate of the reaction would be a nucleophilic allylcobalt(I) species generated via cleavage of the low reactive allylic C(sp³)-H bond of simple terminal alkenes.

SUBMITTER: Mita T

PROVIDER: S-EPMC6122116 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed nucleophilic addition of the allylic C(sp<sup>3</sup>)-H bond of simple alkenes to ketones.

Mita Tsuyoshi T Uchiyama Masashi M Michigami Kenichi K Sato Yoshihiro Y

Beilstein journal of organic chemistry 20180802

We herein describe a cobalt/Xantphos-catalyzed regioselective addition of simple alkenes to acetophenone derivatives, affording branched homoallylic alcohols in high yields with perfect branch selectivities. The intermediate of the reaction would be a nucleophilic allylcobalt(I) species generated via cleavage of the low reactive allylic C(sp<sup>3</sup>)-H bond of simple terminal alkenes. ...[more]

PMID: 30202455

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