Ontology highlight
ABSTRACT:
SUBMITTER: Jones MC
PROVIDER: S-EPMC6122981 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jones Matthew C MC Askari Janet A JA Humphries Jonathan D JD Humphries Martin J MJ
The Journal of cell biology 20180621 9
In most tissues, anchorage-dependent growth and cell cycle progression are dependent on cells engaging extracellular matrices (ECMs) via integrin-receptor adhesion complexes. In a highly conserved manner, cells disassemble adhesion complexes, round up, and retract from their surroundings before division, suggestive of a primordial link between the cell cycle machinery and the regulation of cell adhesion to the ECM. In this study, we demonstrate that cyclin-dependent kinase 1 (CDK1) mediates this ...[more]