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Combining immunotherapy with radiation therapy in thoracic oncology.


ABSTRACT: Thoracic malignancies comprise some of the most common and deadly cancers. Immunotherapies have been proven to improve survival outcomes for patients with advanced non-small cell lung cancer (NSCLC) and show great potential for patients with other thoracic malignancies. Radiation therapy (RT), an established and effective treatment for thoracic cancers, has acted synergistically with immunotherapies in preclinical studies. Ongoing clinical trials are exploring the clinical benefits of combining RT with immunotherapies and the optimal manner in which to deliver these complementary treatments.

SUBMITTER: Badiyan SN 

PROVIDER: S-EPMC6123189 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Combining immunotherapy with radiation therapy in thoracic oncology.

Badiyan Shahed N SN   Roach Michael C MC   Chuong Michael D MD   Rice Stephanie R SR   Onyeuku Nasarachi E NE   Remick Jill J   Chilukuri Srinivas S   Glass Erica E   Mohindra Pranshu P   Simone Charles B CB  

Journal of thoracic disease 20180801 Suppl 21


Thoracic malignancies comprise some of the most common and deadly cancers. Immunotherapies have been proven to improve survival outcomes for patients with advanced non-small cell lung cancer (NSCLC) and show great potential for patients with other thoracic malignancies. Radiation therapy (RT), an established and effective treatment for thoracic cancers, has acted synergistically with immunotherapies in preclinical studies. Ongoing clinical trials are exploring the clinical benefits of combining  ...[more]

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