Ontology highlight
ABSTRACT:
SUBMITTER: Shaltouki A
PROVIDER: S-EPMC6123262 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Shaltouki Atossa A Hsieh Chung-Han CH Kim Min Joo MJ Wang Xinnan X
Acta neuropathologica 20180609 4
Alpha-synuclein is a component of Lewy bodies, the pathological hallmark of Parkinson's disease (PD), and is also mutated in familial PD. Here, by extensively analyzing PD patient brains and neurons, and fly models, we show that alpha-synuclein accumulation results in upregulation of Miro protein levels. Miro is a motor/adaptor on the outer mitochondrial membrane that mediates mitochondrial motility, and is removed from damaged mitochondria to facilitate mitochondrial clearance via mitophagy. PD ...[more]