Targeting Tumor Metabolism With Statins During Treatment for Advanced-stage Pancreatic Cancer.

ABSTRACT:

Introduction

A growing body of preclinical data suggests that statins may exert potent antitumor effects, yet the interactions of these medications with standard therapies and clinical outcomes in this population is less clear. We assessed the impact of statin use on outcomes in patients with advanced-stage pancreatic adenocarcinoma undergoing various treatments.

Materials and methods

After institutional review board approval, we conducted a retrospective-cohort study consisting of 303 newly diagnosed advanced-stage pancreatic adenocarcinoma patients to determine the impact of statin use on outcomes. Univariate and multivariable Cox proportional hazard regression models were utilized to estimate hazard ratios (HRs). Time-to-event was estimated using Kaplan-Meier survival ana

SUBMITTER: Iarrobino NA 

PROVIDER: S-EPMC6123314 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature