Ontology highlight
ABSTRACT:
SUBMITTER: Valanejad L
PROVIDER: S-EPMC6123626 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Valanejad Leila L Cast Ashley A Wright Mary M Bissig Karl-Dimiter KD Karns Rebekah R Weirauch Matthew T MT Timchenko Nikolai N
Communications biology 20180611
Hepatoblastoma (HBL) is a pediatric liver cancer that affects children under the age of three. Reduction of tumor suppressor proteins (TSPs) is commonly seen in liver cancer. However, in our studies we find that aggressive, chemo-resistant HBLs exhibit an elevation of TSPs. HBL patients with a classic phenotype have reduced TSP levels, but patients with aggressive HBL express elevated TSPs that undergo posttranslational modifications, eliminating their tumor suppression activities. Here we ident ...[more]