Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC6123647 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kim Jihye J Kwon Jun Tae JT Jeong Juri J Kim Jaehwan J Hong Seong Hyeon SH Kim Jinyoung J Park Zee Yong ZY Chung Kyung Hwun KH Eddy Edward M EM Cho Chunghee C
EMBO reports 20180719 9
Spermatogenesis is a tightly regulated process involving germ cell-specific and germ cell-predominant genes. Here we investigate a novel germ cell-specific gene, Spatc1l (spermatogenesis and centriole associated 1 like). Expression analyses show that SPATC1L is expressed in mouse and human testes. We find that mouse SPATC1L localizes to the neck region in testicular sperm. Moreover, SPATC1L associates with the regulatory subunit of protein kinase A (PKA). Using CRISPR/Cas9-mediated genome engine ...[more]