Ontology highlight
ABSTRACT:
SUBMITTER: De Backer JF
PROVIDER: S-EPMC6123657 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
De Backer Jean-François JF Monlezun Stéphanie S Detraux Bérangère B Gazan Adeline A Vanopdenbosch Laura L Cheron Julian J Cannazza Giuseppe G Valverde Sébastien S Cantacorps Lídia L Nassar Mérie M Venance Laurent L Valverde Olga O Faure Philippe P Zoli Michele M De Backer Olivier O Gall David D Schiffmann Serge N SN de Kerchove d'Exaerde Alban A
EMBO reports 20180712 9
Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one of these genes, Maged1, in the control of behaviours related to drug addiction. Mice lacking Maged1 are insensitive to the behavioural effects of cocaine as assessed by locomotor sensitization, conditioned place preference (CPP) and drug self-administration. Electrophysiological ...[more]