Ontology highlight
ABSTRACT:
SUBMITTER: Michaud SA
PROVIDER: S-EPMC6123701 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Michaud Sarah A SA Sinclair Nicholas J NJ Pětrošová Helena H Palmer Andrea L AL Pistawka Adam J AJ Zhang Suping S Hardie Darryl B DB Mohammed Yassene Y Eshghi Azad A Richard Vincent R VR Sickmann Albert A Borchers Christoph H CH
Communications biology 20180627
Mouse is the predominant experimental model for the study of human disease due, in part, to phylogenetic relationship, ease of breeding, and the availability of molecular tools for genetic manipulation. Advances in genome-editing methodologies, such as CRISPR-Cas9, enable the rapid production of new transgenic mouse strains, necessitating complementary high-throughput and systematic phenotyping technologies. In contrast to traditional protein phenotyping techniques, multiple reaction monitoring ...[more]