Ontology highlight
ABSTRACT:
SUBMITTER: Perkons NR
PROVIDER: S-EPMC6123816 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Perkons Nicholas R NR Stein Elliot J EJ Nwaezeapu Chike C Wildenberg Joseph C JC Saleh Kamiel K Itkin-Ofer Roni R Ackerman Daniel D Soulen Michael C MC Hunt Stephen J SJ Nadolski Gregory J GJ Gade Terence P TP
Communications biology 20180517
Minimally invasive ablation strategies enable locoregional treatment of tumors. One such strategy, electrolytic ablation, functions through the local delivery of direct current without thermal effects, facilitating enhanced precision. However, the clinical application of electrolytic ablation is limited by an incompletely characterized mechanism of action. Here we show that acid and base production at the electrodes precipitates local pH changes causing the rapid cell death that underlies macros ...[more]