Identification of Chloride Intracellular Channel Protein 3 as a Novel Gene Affecting Human Bone Formation.

ABSTRACT: Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. The bone building cells, osteoblasts, are derived from mesenchymal stromal cells (MSCs); however, with increasing age osteogenic differentiation is diminished and more adipocytes are seen in the bone marrow, suggesting a shift in MSC lineage commitment. Identification of specific factors that stimulate osteoblast differentiation from human MSCs may deliver therapeutic targets to treat osteoporosis. The aim of this study was to identify novel genes involved in osteoblast differentiation of human bone marrow-derived MSCs (hMSCs). We identified the gene chloride intracellular channel protein 3 (CLIC3) to be strongly upregulated during MSC-derived os

SUBMITTER: Brum AM 

PROVIDER: S-EPMC6124162 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature