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Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading.

ABSTRACT: Previous work has shown that the soluble murine BMPR1A-fusion protein (mBMPR1A-mFc) binds to BMP2 and BMP4 with high affinity, preventing downstream signaling. Further, treatment of intact and ovariectomized mice with mBMPR1A-mFc leads to increased bone mass, and improved bone microarchitecture and strength, via increased bone formation and reduced resorption. In this study, we tested the effects of mBMPR1A-mFc on disuse-induced bone loss caused by 21 days of hindlimb unloading (HLU) via tail suspension versus cage controls (CONs). Adult female C57BL/6J mice (12 weeks old) were assigned to one of four groups (n?=?10 each): CON-VEH; CON-mBMPR1A-mFc; HLU-VEH; and HLU-mBMPR1A-mFc. Mice were injected subcutaneously with VEH or mBMPR1A-mFc (4.5?mg/kg, 2×/week). Leg BMD declined in the HLU-VEH group (-5.3%?±?1.3%), whereas it was unchanged in HLU-mBMPR1A-mFc (-0.3%?±?0.9%, p?p?p?

SUBMITTER: Ko FC 

PROVIDER: S-EPMC6124165 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading.

Ko Frank C FC   Van Vliet Miranda M   Ellman Rachel R   Grasso Daniel D   Brooks Daniel J DJ   Spatz Jordan M JM   Conlon Chrissy C   Aguirre J Ignacio JI   Wronski Thomas J TJ   Bouxsein Mary L ML  

JBMR plus 20171009 2

Previous work has shown that the soluble murine BMPR1A-fusion protein (mBMPR1A-mFc) binds to BMP2 and BMP4 with high affinity, preventing downstream signaling. Further, treatment of intact and ovariectomized mice with mBMPR1A-mFc leads to increased bone mass, and improved bone microarchitecture and strength, via increased bone formation and reduced resorption. In this study, we tested the effects of mBMPR1A-mFc on disuse-induced bone loss caused by 21 days of hindlimb unloading (HLU) via tail su  ...[more]

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