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Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells.

ABSTRACT: The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied. Skeletal stem cells on nacre surfaces exhibited an increase in cell area, increase in expression of osteogenic markers ALP (p?OCN (p?p?p?

SUBMITTER: Waddell SJ

PROVIDER: S-EPMC6124183 | biostudies-literature | 2018 Jan-Dec

REPOSITORIES: biostudies-literature

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Biomimetic oyster shell-replicated topography alters the behaviour of human skeletal stem cells.

Waddell Shona J SJ de Andrés María C MC Tsimbouri Penelope M PM Alakpa Enateri V EV Cusack Maggie M Dalby Matthew J MJ Oreffo Richard Oc RO

Journal of tissue engineering 20180101

The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from <i>Pinctada maxima</i> shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of <i>P. maxima</i> surfaces, nacre and prism. To in ...[more]

PMID: 30202512

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