Ontology highlight
ABSTRACT:
SUBMITTER: Salvatierra J
PROVIDER: S-EPMC6124407 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Salvatierra Juan J Castro Joel J Erickson Andelain A Li Qian Q Braz Joao J Gilchrist John J Grundy Luke L Rychkov Grigori Y GY Deiteren Annemie A Rais Rana R King Glenn F GF Slusher Barbara S BS Basbaum Allan A Pasricha Pankaj J PJ Brierley Stuart M SM Bosmans Frank F
JCI insight 20180607 11
Functional bowel disorder patients can suffer from chronic abdominal pain, likely due to visceral hypersensitivity to mechanical stimuli. As there is only a limited understanding of the basis of chronic visceral hypersensitivity (CVH), drug-based management strategies are ill defined, vary considerably, and include NSAIDs, opioids, and even anticonvulsants. We previously reported that the 1.1 subtype of the voltage-gated sodium (NaV; NaV1.1) channel family regulates the excitability of sensory n ...[more]