Ontology highlight
ABSTRACT:
SUBMITTER: Fourcade J
PROVIDER: S-EPMC6124410 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Fourcade Julien J Sun Zhaojun Z Chauvin Joe-Marc JM Ka Mignane M Davar Diwakar D Pagliano Ornella O Wang Hong H Saada Sofiane S Menna Carmine C Amin Rada R Sander Cindy C Kirkwood John M JM Korman Alan J AJ Zarour Hassane M HM
JCI insight 20180726 14
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expression and decreased expression of its competing costimulatory receptor CD226 as compared with CD4+ effector T cells, resulting in an increased TIGIT/CD226 ratio. Tregs failed to upregulate CD226 upon T cell activation. TIGIT+ Tregs are highly suppressive ...[more]