Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC6124527 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Lee Juhyun J Vedula Vijay V Baek Kyung In KI Chen Junjie J Hsu Jeffrey J JJ Ding Yichen Y Chang Chih-Chiang CC Kang Hanul H Small Adam A Fei Peng P Chuong Cheng-Ming CM Li Rongsong R Demer Linda L Packard René R Sevag RRS Marsden Alison L AL Hsiai Tzung K TK
JCI insight 20180712 13
Hemodynamic shear force has been implicated as modulating Notch signaling-mediated cardiac trabeculation. Whether the spatiotemporal variations in wall shear stress (WSS) coordinate the initiation of trabeculation to influence ventricular contractile function remains unknown. Using light-sheet fluorescent microscopy, we reconstructed the 4D moving domain and applied computational fluid dynamics to quantify 4D WSS along the trabecular ridges and in the groves. In WT zebrafish, pulsatile shear str ...[more]