Placental weight and birthweight: the relations with number of daily cigarettes and smoking cessation in pregnancy. A population study.

ABSTRACT:

Background

We studied associations of number of daily cigarettes in the first trimester with placental weight and birthweight in women who smoked throughout pregnancy, and in women who stopped smoking after the first trimester.

Methods

We included all women with delivery of a singleton in Norway (n?=?698?891) during 1999-2014, by using data from the Medical Birth Registry of Norway. We assessed dose-response associations by applying linear regression with restricted cubic splines.

Results

In total, 12.6% smoked daily in the first trimester, and 3.7% stopped daily smoking. In women who smoked throughout pregnancy, placental weight and birthweight decreased by number of cigarettes; however, above 11-12 cigarettes we estimated no further decrease (Pnon-linearity?ConclusionsIn women who smoked throughout pregnancy, placental weight and birthweight decreased non-linearly by number of cigarettes in the first trimester. In women who stopped smoking, placental weight was higher than in non-smokers and increased linearly by number of cigarettes; birthweight was almost similar to that of non-smokers.

SUBMITTER: Larsen S 

PROVIDER: S-EPMC6124614 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature