The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis.
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ABSTRACT:
SUBMITTER: Fransen Pettersson N
PROVIDER: S-EPMC6124744 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis.
Fransén Pettersson Nina N Deronic Adnan A Nilsson Julia J Hannibal Tine D TD Hansen Lisbeth L Schmidt-Christensen Anja A Ivars Fredrik F Holmberg Dan D
PloS one 20180905 9
Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, even when the treatment was initiated after onset of disease. The reduced disease phenotype was associa ...[more]
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