Ontology highlight
ABSTRACT:
SUBMITTER: Divakaruni AS
PROVIDER: S-EPMC6125190 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Divakaruni Ajit S AS Hsieh Wei Yuan WY Minarrieta Lucía L Duong Tin N TN Kim Kristen K O KKO Desousa Brandon R BR Andreyev Alexander Y AY Bowman Caitlyn E CE Caradonna Kacey K Dranka Brian P BP Ferrick David A DA Liesa Marc M Stiles Linsey L Rogers George W GW Braas Daniel D Ciaraldi Theodore P TP Wolfgang Michael J MJ Sparwasser Tim T Berod Luciana L Bensinger Steven J SJ Murphy Anne N AN
Cell metabolism 20180628 3
Long-chain fatty acid (LCFA) oxidation has been shown to play an important role in interleukin-4 (IL-4)-mediated macrophage polarization (M(IL-4)). However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 with high concentrations of etomoxir that far exceed what is required to inhibit enzyme activity (EC<sub>90</sub> < 3 μM). We employ genetic and pharmacologic models to demonstrate that LCFA oxidation is largely dispensable for IL-4-driven polarization. ...[more]