(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.

ABSTRACT: The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by 'inheritance system'. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

SUBMITTER: Cosseau C 

PROVIDER: S-EPMC6125318 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature