DNA methylation age is accelerated in alcohol dependence.
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ABSTRACT:
SUBMITTER: Rosen AD
PROVIDER: S-EPMC6125381 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
DNA methylation age is accelerated in alcohol dependence.
Rosen Allison D AD Robertson Keith D KD Hlady Ryan A RA Muench Christine C Lee Jisoo J Philibert Robert R Horvath Steve S Kaminsky Zachary A ZA Lohoff Falk W FW
Translational psychiatry 20180905 1
Alcohol dependence (ALC) is a chronic, relapsing disorder that increases the burden of chronic disease and significantly contributes to numerous premature deaths each year. Previous research suggests that chronic, heavy alcohol consumption is associated with differential DNA methylation patterns. In addition, DNA methylation levels at certain CpG sites have been correlated with age. We used an epigenetic clock to investigate the potential role of excessive alcohol consumption in epigenetic aging ...[more]
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