Ontology highlight
ABSTRACT:
SUBMITTER: Casar B
PROVIDER: S-EPMC6125387 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180905 1
RAS GTPases are frequently mutated in human cancer. H- and NRAS isoforms are distributed over both plasma-membrane and endomembranes, including the Golgi complex, but how this organizational context contributes to cellular transformation is unknown. Here we show that RAS at the Golgi is selectively activated by apoptogenic stimuli and antagonizes cell survival by suppressing ERK activity through the induction of PTPRκ, which targets CRAF for dephosphorylation. Consistently, in contrast to what o ...[more]