Ontology highlight
ABSTRACT:
SUBMITTER: Xiao T
PROVIDER: S-EPMC6125388 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cell death & disease 20180905 9
Vasculogenic mimicry (VM) is a functional microcirculation pattern formed by aggressive tumor cells and is related to the metastasis and poor prognosis of many cancer types, including hepatocellular carcinoma (HCC). Thus far, no effective drugs have been developed to target VM. In this study, patients with liver cancer exhibited reduced VM in tumor tissues after treatment with Rhizoma Paridis. Polyphyllin I (PPI), which is the main component of Rhizoma Paridis, inhibited VM formation in HCC line ...[more]