Ontology highlight
ABSTRACT:
SUBMITTER: Pongsuchart M
PROVIDER: S-EPMC6125443 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Pongsuchart Mongkol M Kuchimaru Takahiro T Yonezawa Sakiko S Tran Diem Thi Phuong DTP Kha Nguyen The NT Hoang Ngoc Thi Hong NTH Kadonosono Tetsuya T Kizaka-Kondoh Shinae S
Cancer science 20180724 9
Lung metastasis is a major cause of mortality in patients with osteosarcoma (OS). A better understanding of the molecular mechanism of OS lung metastasis may facilitate development of new therapeutic strategies to prevent the metastasis. We have established high- and low-metastatic sublines (LM8-H and LM8-L, respectively) from Dunn OS cell line LM8 by using in vivo image-guided screening. Among the genes whose expression was significantly increased in LM8-H compared to LM8-L, the transcription f ...[more]