Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC6125445 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Lu Yichen Y Wang Ya Y Xu He H Shi Chen C Jin Fengyan F Li Wei W
Cancer science 20180727 9
Autophagy plays an important role in multiple myeloma (MM) for homeostasis, survival and drug resistance, but which genes participate in this process is unclear. We identified several cytoskeleton genes upregulated in MM patients by gene expression profiling (GEP) datasets; in particular, patients with high profilin 1 (PFN1) expression had poor prognosis in MM. In vitro, overexpressed PFN1 promotes proliferation and bortezomib (BTZ) resistance in MM cells. Further study indicated overexpression ...[more]