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Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer.


ABSTRACT: We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in Haemophilus influenzae, suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective treatment against invasive meningococcal disease.

SUBMITTER: Hong E 

PROVIDER: S-EPMC6125549 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer.

Hong Eva E   Deghmane Ala-Eddine AE   Taha Muhamed-Kheir MK  

Antimicrobial agents and chemotherapy 20180827 9


We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in <i>Haemophilus influenzae</i>, suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective trea  ...[more]

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