Ontology highlight
ABSTRACT:
SUBMITTER: Pires de Mello CP
PROVIDER: S-EPMC6125552 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Pires de Mello Camilly P CP Tao Xun X Kim Tae Hwan TH Vicchiarelli Michael M Bulitta Jürgen B JB Kaushik Ajeet A Brown Ashley N AN
Antimicrobial agents and chemotherapy 20180827 9
Zika virus (ZIKV) infection is associated with serious, long-term neurological manifestations. There are currently no approved therapies for the treatment or prevention of ZIKV infection. Favipiravir (FAV) is a viral polymerase inhibitor with broad-spectrum activity. Our prior studies used static FAV concentrations and demonstrated promising activity. However, the anti-ZIKV activity of dynamic FAV concentrations has never been evaluated in a human cell line. Here we employed the hollow-fiber inf ...[more]